公开(公告)号：EP0669336A4

公开(公告)日：1996-04-10

申请号：EP94927055

申请日：1994-09-16

申请人： MEIJI SEIKA CO

发明人： ATSUMI KUNIO ,  UMEMURA EIJIRO ,  KANO YUKO ,  SHIOKAWA SOHJIRO ,  KUDO TOSHIAKI ,  TSUSHIMA MASAKI ,  IWAMATSU KATSUYOSHI ,  TAMURA ATSUSHI ,  SHIBAHARA SEIJI

IPC分类号： C07D501/00 ,  C07D501/46 ,  C07D519/06 ,  C07D519/00 ,  A61K31/545

CPC分类号： C07D501/00

摘要： A compound represented by general formula (I), i.e., a cephem derivative having an (un)substituted imidazo[5,1-b]thiazolium-6-yl group at the 3-position of the ring, wherein X represents CH or N; R1 represents H, alkyl, alkenyl, etc.; and R?2, R3, R4 and R5¿ represent each H, alkyl, carbamoyl, amino, etc. This compound has an excellent antibacterial activity and is useful as a remedy for various types of microbism.

公开(公告)号：EP0774466A4

公开(公告)日：1998-09-02

申请号：EP96914440

申请日：1996-05-24

申请人： MEIJI SEIKA CO

发明人： UMEMURA EIJIRO ,  ATSUMI KUNIO ,  IWAMATSU KATSUYOSHI ,  TAMURA ATSUSHI

IPC分类号： A61K31/545 ,  A61P31/04 ,  C07D501/00 ,  C07D501/56 ,  C07D519/06 ,  C07D519/00

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： Compounds represented by general formula (I) and having a β-(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad antimicrobial spectrum and exerts potent antimicrobial effects on Gram-positive bacteria, Gram-negative bacteria and even resistant bacteria. In formula (I) X represents CH or N; R1 represents hydrogen or an amino protecting group; R2 represents hydrogen, C¿1-6? alkyl, C3-7 cycloalkyl or a hydroxy protecting group; R?3¿ is not present or represents hydrogen, a cation forming a salt or a carboxy protecting group; R?4, R5 and R6¿ may be the same or different and each represents hydrogen or C¿1-6? alkyl; R?7+¿ is not present or represents a cation of C¿1-6? alkyl; and n is an integer of 0 or 1.