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    DEXTRAN REDUCED IN BORON CONTENT, PROCESS FOR PRODUCING THE SAME, AND DEXTRAN PACKED IN CONTAINER IN SOLUTION STATE
    1.
    发明公开
    DEXTRAN REDUCED IN BORON CONTENT, PROCESS FOR PRODUCING THE SAME, AND DEXTRAN PACKED IN CONTAINER IN SOLUTION STATE 有权
    DEXTRAN MIT GERINGEM BORGEHALT，VERFAHREN ZU DEREN HERSTELLUNG ANDD DEXTRAN EINERLÖSUNGVERPACKT IN EINEMBEHÄLTER

    公开(公告)号：EP1024148A4

    公开(公告)日：2000-12-20

    申请号：EP98947782

    申请日：1998-10-07

    申请人： MEITO SANGYO KK ,  OTSUKA PHARMA CO LTD

    发明人： MACHIDA HARUO ,  KATO SHIGEAKI ,  HIRATA YUUKI ,  AOKI MITSUO ,  KOBATAKE HIDEKI

    IPC分类号： A61K31/721 ,  C08B37/02 ,  A61K31/715

    CPC分类号： C08B37/0021 ,  A61K31/721

    摘要： The present invention relates to dextran whose boron content is reduced to a value less than 0.30 mu g/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. Dextran of the present invention is obtained by treating a boron-containing dextran with a lower alcohol, and said dextran has such a characteristic that deposition is inhibited or the deposition rate is drastically reduced when using it in the form of a solution. Therefore, an isotonic sodium chloride solution of said dextran is suitably used as substitute plasma or external perfusate in an operation.

    摘要翻译： 硼原子换算成硼含量低于0.30μg/ g（干燥状态）的葡聚糖; 生产该工艺的方法; 和处于溶液状态并容纳在容器中的葡聚糖。 该葡聚糖通过用低级醇处理富含硼的葡聚糖来获得。 葡聚糖的特征是在溶液状态下使用时抑制沉淀，或沉淀速率显着降低。 因此，因为这种葡聚糖在例如生理盐水中的溶液作为高储存稳定性，所以它适合用作等离子体膨胀器或用于手术的体外循环液等。