公开(公告)号：EP1677599A4

公开(公告)日：2008-10-22

申请号：EP04795564

申请日：2004-10-18

申请人： MERCK & CO INC

发明人： WAI JOHN S ,  FISHER THORSTEN E ,  ZHUANG LINGHANG ,  STAAS DONNETTE D ,  LYLE TERRY A ,  KIM BOYOUNG ,  EMBREY MARK W ,  WISCOUNT CATHERINE M ,  TRAN LEKHANH O ,  EGBERTSON MELISSA ,  SAVAGE KELLY L

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/50 ,  C07D239/00 ,  C07D471/00 ,  C07D471/14 ,  C07D487/00 ,  C07D491/00

CPC分类号： C07D471/14

摘要： Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.