专利检索 ap:("MERCK & CO INC" OR "MERCK SHARP & DOHME") AND inv:"HANDS DAVID" 第 1 页

1.

发明公开
PROCESS FOR 5- 2(R)- 1(R)- 3,5-BIS(TRIFLUOROMETHYL)PHENYL|ETHOXY|-3(S)-(4-FLUOROPHENYL)-4-MORPHOLINYL|METHYL|-1,2-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE 有权
标题翻译：程序对5-CC2（R）-C 1（R）-ç3,5双（三氟甲基）苯基]乙氧基] -3-（S） - （4-氟苯基）-4-吗啉基]甲基] -1,2- 二氢-3H-1,2,4-三唑-3-酮

公开(公告)号：EP1499611A4

公开(公告)日：2006-05-03

申请号：EP03726338

申请日：2003-04-17

申请人： MERCK & CO INC , MERCK SHARP & DOHME

发明人： HUFFMAN MARK , KABA MAHMOUD S , PAYACK JOSEPH F , HANDS DAVID

IPC分类号： C07D413/06 , A61K31/5377 , A61P1/12 , A61P25/18 , A61P29/00 , A61P43/00 , C07D265/32 , C07D413/02

CPC分类号： C07D413/06 , C07D265/32

摘要： The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.