公开(公告)号：EP0912537B1

公开(公告)日：2004-05-12

申请号：EP97932424.1

申请日：1997-06-27

申请人： MERCK & CO., INC.

发明人： DESMOND, Richard ,  DOLLING, Ulf, H. ,  FREY, Lisa, F. ,  TILLYER, Richard, D. ,  TSCHAEN, David, M.

IPC分类号： C07D307/38

CPC分类号： C07D307/38

摘要： The invention encompasses a process for making compounds of Formula (I) useful in the treatment of inflammation and other cyclooxygenase-2 mediated diseases.

公开(公告)号：EP1345933A2

公开(公告)日：2003-09-24

申请号：EP01994243.2

申请日：2001-12-14

申请人： Merck & Co., Inc.

发明人： DESMOND, Richard ,  CONLON, David, A. ,  DRAHUS, Antoinette ,  HO, Guo-Jie ,  PIPIK, Brenda ,  LEBLOND, Carl ,  VAILAYA, Anant

IPC分类号： C07D413/10

CPC分类号： C07D413/10

摘要： The present invention is directed to a process to synthesize 6-[1-methyl-1-(methylsulfonyl)ethyl]-8-[3(E)-2-[3-methyl-1,2,4-oxadizol-5-yl]-2-[4-(methylsulfonyl)phenyl]ethenyl]phenyl]quinoline and its benzenesulfonic acid salt.

公开(公告)号：EP0701558A1

公开(公告)日：1996-03-20

申请号：EP94919423.0

申请日：1994-06-08

申请人： MERCK & CO. INC.

发明人： CAI, Dongwei ,  DESMOND, Richard ,  SHI, Yao-Jun ,  TSCHAEN, David, M. ,  VERHOEVEN, Thomas, R.

IPC分类号： C07D491

CPC分类号： C07D491/10

摘要： The present invention is directed to a process of making spirocycles of general structural formula (I), where R1 is selected from the group consisting of CO-CO1-3 alkyl, cyano, carboxy, carboxy C1-6 alkyl ester, carboxamide, C1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, C1-6 methanesulfonamide and halogen; R2 is selected from the group consisting of keto or alcohol, R3 is cyano, resulting in compounds which are Class III antiarrhythmic.

公开(公告)号：EP1345933B1

公开(公告)日：2005-06-22

申请号：EP01994243.2

申请日：2001-12-14

申请人： Merck & Co., Inc.

发明人： DESMOND, Richard ,  CONLON, David, A. ,  DRAHUS, Antoinette ,  HO, Guo-Jie ,  PIPIK, Brenda ,  LEBLOND, Carl ,  VAILAYA, Anant

IPC分类号： C07D413/10

CPC分类号： C07D413/10

摘要： The present invention is directed to a process to synthesize 6-[1-methyl-1-(methylsulfonyl)ethyl]-8-[3(E)-2-[3-methyl-1,2,4-oxadizol-5-yl]-2-[4-(methylsulfonyl)phenyl]ethenyl]phenyl]quinoline and its benzenesulfonic acid salt.

公开(公告)号：EP0912537A1

公开(公告)日：1999-05-06

申请号：EP97932424.0

申请日：1997-06-27

申请人： MERCK & CO., INC.

发明人： DESMOND, Richard ,  DOLLING, Ulf, H. ,  FREY, Lisa, F. ,  TILLYER, Richard, D. ,  TSCHAEN, David, M.

IPC分类号： C07D307

CPC分类号： C07D307/38

摘要： The invention encompasses a process for making compounds of Formula (I) useful in the treatment of inflammation and other cyclooxygenase-2 mediated diseases.