公开(公告)号：EP0937068B1

公开(公告)日：2002-03-13

申请号：EP97913800.5

申请日：1997-10-24

申请人： MERCK & CO., INC.

发明人： BREEN, Patrick ,  DIENEMANN, Erik, A. ,  EPSTEIN, Albert, D. ,  LARSON, Karen, A. ,  KENNEDY, Michael, T. ,  MAHADEVAN, Hari

IPC分类号： C07D403/10

CPC分类号： C07D403/10

摘要： Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure (I). This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.

公开(公告)号：EP0937068A1

公开(公告)日：1999-08-25

申请号：EP97913800.0

申请日：1997-10-24

申请人： MERCK & CO., INC.

发明人： BREEN, Patrick ,  DIENEMANN, Erik, A. ,  EPSTEIN, Albert, D. ,  LARSON, Karen, A. ,  KENNEDY, Michael, T. ,  MAHADEVAN, Hari

IPC分类号： C07D403

CPC分类号： C07D403/10

摘要： Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure (I). This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.