公开(公告)号：EP1090001A1

公开(公告)日：2001-04-11

申请号：EP99931871.0

申请日：1999-06-23

申请人： MERCK & CO., INC.

发明人： RATCLIFFE, Ronald, W. ,  WADDELL, Sherman, T. ,  MORGAN, Jerry, D., II ,  BLIZZARD, Timothy, A.

IPC分类号： C07D477/14 ,  A61K31/40

CPC分类号： C07D477/14

摘要： Compounds of formula (I): as well as pharmaceutically acceptable salts thereof are disclosed.

公开(公告)号：EP1689768A2

公开(公告)日：2006-08-16

申请号：EP04821674.1

申请日：2004-11-19

申请人： Merck & Co., Inc.

发明人： BLIZZARD, Timothy, A. ,  GUDE, Candido ,  MORGAN, Jerry, D., II

IPC分类号： C07J1/00

CPC分类号： C07J1/0022 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.

公开(公告)号：EP1689767A1

公开(公告)日：2006-08-16

申请号：EP04811561.2

申请日：2004-11-19

申请人： Merck & Co., Inc.

发明人： BLIZZARD, Timothy, A. ,  GUDE, Candido ,  MORGAN, Jerry, D., II

IPC分类号： C07J1/00 ,  A61K31/56

CPC分类号： C07J41/0094 ,  C07J1/00 ,  C07J1/0022

摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget’s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.