公开(公告)号：EP0484071A3

公开(公告)日：1992-11-25

申请号：EP91309915.6

申请日：1991-10-28

申请人： MERCK & CO. INC.

发明人： Friedman, Paul A. ,  Emini, Emilio A. ,  Nunberg, Jack ,  Quintero, Julio C.

IPC分类号： A61K31/44 ,  A61K31/70 ,  A61K31/505

CPC分类号： A61K31/70 ,  A61K31/44 ,  A61K2300/00

摘要： The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

公开(公告)号：EP0484071A2

公开(公告)日：1992-05-06

申请号：EP91309915.6

申请日：1991-10-28

申请人： MERCK & CO. INC.

发明人： Friedman, Paul A. ,  Emini, Emilio A. ,  Nunberg, Jack ,  Quintero, Julio C.

IPC分类号： A61K31/44 ,  A61K31/70 ,  A61K31/505

CPC分类号： A61K31/70 ,  A61K31/44 ,  A61K2300/00

摘要： The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

摘要翻译： 已经发现某些氨基吡啶酮和抗HIV核苷类似物的组合协同地抑制HIV逆转录酶。 这种组合可用于预防或治疗艾滋病毒感染和艾滋病的治疗，作为化合物，药学上可接受的盐，药物组合物成分的组合，无论是否与其他抗病毒药物，抗感染剂，免疫调节剂， 抗生素或疫苗。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。