公开(公告)号：EP0840728A1

公开(公告)日：1998-05-13

申请号：EP96923210.0

申请日：1996-06-03

申请人： MERCK FROSST CANADA INC.

发明人： GAREAU, Yves ,  LABELLE, Marc ,  DUFRESNE, Claude ,  YERGEY, James ,  CHAURET, Nathalie ,  NICOLI-GRIFFITH, Deborah ,  TRIMBLE, Laird ,  XU, Xin

IPC分类号： C07D215 ,  A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D495

CPC分类号： C07D495/04 ,  C07D215/18

摘要： Compounds of formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.