公开(公告)号：EP1185859A1

公开(公告)日：2002-03-13

申请号：EP00942016.7

申请日：2000-06-06

申请人： MERCK PATENT GmbH ,  GESELLSCHAFT ZUR FÖRDERUNG DER SPEKTROCHEMIEUND ANGEWANDTEN SPEKTROSKOPIE E.V.

发明人： EISENBEISS, Friedhelm ,  STANISLAWSKI, Bernd ,  GREVE, Thomas ,  BENDER, Renate ,  HERGENRÖDER, Roland ,  WEBER, Günther ,  GRASS, Benedikt ,  NEYER, Andreas ,  JÖHNCK, Matthias

IPC分类号： G01N27/447 ,  B01L3/00

CPC分类号： G01N27/44791 ,  B01L3/502738 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N27/44717 ,  G01N27/44743 ,  G01N35/1095

摘要： The invention relates to a device for introducing samples which is used for miniaturized analytical systems. Defined volumina of 0.01 νl up to 100 νl can be introduced due to a specific design of the channel system and the displacement of the liquid volume of a defined channel section. The inventive device is especially useful for a subsequent analysis of the samples by means of isotachophoresis.

公开(公告)号：EP1188047A1

公开(公告)日：2002-03-20

申请号：EP00938768.9

申请日：2000-06-06

申请人： MERCK PATENT GmbH ,  GESELLSCHAFT ZUR FÖRDERUNG DER SPEKTROCHEMIEUND ANGEWANDTEN SPEKTROSKOPIE E.V.

发明人： EISENBEISS, Friedhelm ,  STANISLAWSKI, Bernd ,  GREVE, Thomas ,  BENDER, Renate ,  HERGENRÖDER, Roland ,  WEBER, Günther ,  GRASS, Benedikt ,  NEYER, Andreas ,  JÖHNCK, Matthias ,  SIEPE, Dirk

IPC分类号： G01N27/447 ,  G01N30/60 ,  G01N35/08 ,  G01N15/14 ,  B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/50273 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0415 ,  B29C65/483 ,  B29C65/4835 ,  B29C65/4845 ,  B29C65/526 ,  B29C65/7817 ,  B29C65/7832 ,  B29C65/7847 ,  B29C66/112 ,  B29C66/114 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/8322 ,  B29L2031/756 ,  G01N27/44717 ,  G01N27/4473 ,  G01N27/44791 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/64 ,  G01N30/74 ,  G01N35/085 ,  B29K2023/18 ,  B29K2023/38 ,  B29K2033/12 ,  B29K2063/00 ,  B29K2069/00

摘要： The invention relates to the production and the design of flow-through elements for microstructured analytical systems. The inventive method allows the production of analytical systems from synthetic material that are provided with a liquid- and gas-tight channel structure in which thin-film electrodes may be arranged any place.

公开(公告)号：EP2935309B1

公开(公告)日：2019-01-23

申请号：EP13795434.3

申请日：2013-11-25

申请人： Merck Patent GmbH

发明人： BAUER, Johann ,  RAPP, Almut ,  STANISLAWSKI, Bernd ,  CAPITO, Florian

IPC分类号： C07K1/30 ,  C07K16/00

公开(公告)号：EP2935309A1

公开(公告)日：2015-10-28

申请号：EP13795434.3

申请日：2013-11-25

申请人： Merck Patent GmbH

发明人： BAUER, Johann ,  RAPP, Almut ,  STANISLAWSKI, Bernd ,  CAPITO, Florian

IPC分类号： C07K1/30 ,  C07K16/00

CPC分类号： C07K1/30 ,  C07K1/32 ,  C07K16/00 ,  C07K2317/10

摘要： The present invention relates to the isolation of recombinant and/or biotherapeutic proteins for capture or clarification from cell culture fluid using copolymers. The copolymers used according to the process of the present invention comprise hydrophobic and anionic residues.

摘要翻译： 本发明涉及使用共聚物从细胞培养液中分离用于捕获或澄清的重组和/或生物治疗性蛋白质。 根据本发明方法使用的共聚物包含疏水和阴离子残基。

公开(公告)号：EP1449292A2

公开(公告)日：2004-08-25

申请号：EP02781298.1

申请日：2002-10-30

申请人： MERCK PATENT GmbH

发明人： BENDER, Renate ,  GREVE, Thomas ,  DERWENSKUS, Karl-Heinz ,  JÖHNCK, Matthias ,  STURMFELS, Sigrid ,  STANISLAWSKI, Bernd ,  KANIANSKY, Dusan ,  MAS R, Marián ,  BODOR, Robert

IPC分类号： H02M1/00

CPC分类号： H01M4/8626 ,  H01M8/0232 ,  H01M8/08

摘要： The present invention provides a field generating membrane electrode for contact with an electrolyte solution comprising a wetable membrane which is ion permeable under electric field conditions and an electrically conductive material for connection with a source of electrical charges, characterized in that one side of the membrane is in direct contact with the electrolyte solution and the other side of the membrane is in direct contact with the electrically conductive material and a gas receiving volume. The electrode according to the present invention is especially useful for electrokinetic transport, electrokinetic pumping, electrophoretic transport, isotachophoretic transport, separation of ions or electrochemical reaction of ions.

公开(公告)号：EP1483046A1

公开(公告)日：2004-12-08

申请号：EP03708088.4

申请日：2003-02-10

申请人： MERCK PATENT GmbH

发明人： BENDER, Renate ,  BRENNER, Günter ,  GREVE, Thomas ,  JOEHNCK, Matthias ,  STANISLAWSKI, Bernd ,  SCHMELZ, Michael ,  STURMFELS, Sigrid

IPC分类号： B01J19/00 ,  B01L3/00

CPC分类号： B01J19/0093 ,  B01J2219/0081 ,  B01L2200/027 ,  G01N30/6047 ,  G01N30/6095

摘要： Disclosed is a microcomponent connection system (1) comprising a device for receiving plate-shaped microcomponents (7), a connection block (2), and a lifting device (6) by means of which the microcomponent (7) and the connection block (2) can be pressed against each other. The connection block (2) is provided with electrical and fluidic line terminals (8, 9) and optical line terminals (16), each of which projects in a springy or spring-mounted manner from the lower face of the connection block (2). In order to connect the microcomponent (7) to the assigned line terminals (8, 9, 16), the microcomponent (7) is pressed by the lifting device (6) against the electrical line terminals (8) or fluidic line terminals (9) or optical line terminals (16), which are embodied as electrically conducting spring tongues or as hollow stamps (10), in the direction of the connection block (2).

公开(公告)号：EP1194769A1

公开(公告)日：2002-04-10

申请号：EP00938793.7

申请日：2000-06-15

申请人： MERCK PATENT GmbH

发明人： EISENBEISS, Friedhelm ,  STANISLAWSKI, Bernd ,  GREVE, Thomas ,  BENDER, Renate ,  HERGENRÖDER, Roland ,  WEBER, Günther ,  GRASS, Benedikt ,  NEYER, Andreas ,  JÖHNCK, Matthias ,  SIEPE, Dirk ,  KANIANSKY, Dusan

IPC分类号： G01N27/447 ,  B01L3/00

摘要： The invention relates to an analysis unit for the preparation of samples, comprising at least one through-flow unit which is made of plastic and provided with a micro-structured channel system, an adapter chamber which reversibly accommodates the through-flow unit and at least one detector. The invention is characterized in that at least one channel section is provided with fluidic connections on the respective ends thereof and is used to charge sample volumes ranging between 0.1 and 20 νl with a deviation of less than 5 %, for the most part 1-5 %.

公开(公告)号：EP1188048A1

公开(公告)日：2002-03-20

申请号：EP00940331.2

申请日：2000-06-06

申请人： MERCK PATENT GmbH

发明人： EISENBEISS, Friedhelm ,  STANISLAWSKI, Bernd ,  GREVE, Thomas ,  HERGENRÖDER, Roland ,  WEBER, Günther ,  GRASS, Benedikt ,  NEYER, Andreas ,  JÖHNCK, Matthias

IPC分类号： G01N27/447

CPC分类号： B01L3/502784 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0415 ,  G01N27/44717 ,  G01N27/44743 ,  G01N27/44791

摘要： The invention relates to a device for withdrawing defined components of samples from the separation channel and transporting them to another channel after a preparative or analytical liquid phase separation in flat, miniaturized analytical systems. The withdrawal device can be directly integrated into the analytical system by positioning detectors, for example for measuring the conductivity, any place in the analytical system.