公开(公告)号：EP3226689A4

公开(公告)日：2018-06-13

申请号：EP15866163

申请日：2015-12-01

申请人： MERCK SHARP & DOHME

发明人： FISCHER CHRISTIAN ,  BOGEN STEPHANE L ,  CHILDERS MATTHEW L ,  LLINAS FRANCESC XAVIER FRADERA ,  ELLIS J MICHAEL ,  ESPOSITE SARA ,  HOFFMAN DAWN M ,  HUANG CHUNHUI ,  KATTAR SOLOMON ,  KIM ALEXANDER J ,  LAMPE JOHN W ,  MACHACEK MICHELLE R ,  MCMASTERS DANIEL R ,  PARKER DANN L JR ,  REUTERSHAN MICHAEL ,  SCIAMMETTA NUNZIO ,  SHAO PENGCHENG P ,  SLOMAN DAVID L ,  SUN WANYING ,  UJJAINWALLA FEROZE ,  WU ZHICAI

IPC分类号： A61K31/551 ,  A61P35/00 ,  C07D471/04 ,  C07D471/14 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D519/00

摘要： The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.