公开(公告)号：EP1756114A4

公开(公告)日：2010-05-19

申请号：EP05743968

申请日：2005-05-03

申请人： MERCK SHARP & DOHME

发明人： WAI JOHN S ,  VACCA JOSEPH P ,  ZHUANG LINGHANG ,  KIM BOYOUNG ,  LYLE TERRY A ,  WISCOUNT CATHERINE M ,  EGBERTSON MELISSA S ,  NEILSON LOU ANNE ,  EMBREY MARK ,  FISHER THORSTEN E ,  STAAS DONNETTE D

IPC分类号： C07D487/14 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  C07D487/12

CPC分类号： A61K31/5025 ,  C07D487/14

摘要： Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.