公开(公告)号：EP2488028A4

公开(公告)日：2013-05-01

申请号：EP10823840

申请日：2010-10-05

申请人： MERCK SHARP & DOHME

发明人： BOGEN STEPHANE L ,  MA YAO ,  WANG YAOLIN ,  LAHUE BRIAN ROBERT ,  NAIR LATHA G ,  SHIZUKA MANAMI ,  VOSS MATTHEW ERNST ,  KIROVA-SNOVER MARGARITA ,  PAN WEIDONG ,  TIAN YUAN ,  KULKARNI BHEEMASHANKAR A ,  GIBEAU CRAIG R ,  LIU YUAN ,  SCAPIN GIOVANNA ,  RINDGEN DIANE ,  DOLL RONALD J ,  GUZI TIMOTHY J ,  HICKLIN DANNY J ,  NOMEIR AMIN ,  SEIDEL-DUGAN CYNTHIA ,  SHIPPS GERALD W JR ,  MACCOSS MALCOLM

IPC分类号： C07D401/14 ,  C07D409/14

CPC分类号： C07D401/14 ,  C07D409/14

摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.