公开(公告)号：EP3294297A1

公开(公告)日：2018-03-21

申请号：EP16796942

申请日：2016-05-10

申请人： MERCK SHARP & DOHME

发明人： SHEN DONG MING ,  QIAN XIAOXIA ,  HARPER BART ,  YANG MENG ,  WANG DEPING ,  BO YINGJIAN

IPC分类号： A61K31/505 ,  A61K31/513 ,  C07D233/96 ,  C07D239/24

CPC分类号： C07D487/04 ,  C07D239/38 ,  C07D239/42 ,  C07D239/52 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.