公开(公告)号：EP2948458A4

公开(公告)日：2016-07-27

申请号：EP14743619

申请日：2014-01-22

申请人： MERCK SHARP & DOHME

发明人： WU HAO ,  KIM RONALD M ,  LIU JIAN ,  GAO XIAOLEI ,  BOGA SOBHANA BABU ,  GUIADEEN DEODIALSINGH ,  KOZLOWSKI JOSEPH ,  YU WENSHENG ,  ANAND RAJAN ,  YU YOUNONG ,  SELYUTIN OLEG B ,  GAO YING-DUO ,  LIU SHILAN ,  YANG CHUNDAO ,  WANG HONGJIAN

IPC分类号： C07D519/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  C07D487/04

CPC分类号： C07D491/048 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61K45/06 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.