公开(公告)号：EP3197455A4

公开(公告)日：2018-04-04

申请号：EP15845304

申请日：2015-09-23

申请人： MERCK SHARP & DOHME ,  MSD R & D CHINA CO LTD

发明人： CAI JIAQIANG ,  COLANDREA VINCENT ,  CRESPO ALEJANDRO ,  DEBENHAM JOHN ,  DU XIAOXING ,  GUIADEEN DEODIALSINGH ,  LIU PING ,  LIU RONGQIANG ,  MADSEN DUGGAN CRISTINA B ,  MCCOY JOSHUA G ,  QUAN WEIGUO ,  SINZ CHRISTOPHER ,  WANG LIPING

IPC分类号： C07D215/56 ,  A61K31/436 ,  A61P7/06 ,  C07D221/22 ,  C07D417/06 ,  C07D471/04 ,  C07D491/052

CPC分类号： C07D491/052 ,  C07D215/56 ,  C07D221/22 ,  C07D417/06 ,  C07D471/04

摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：EP2257170A4

公开(公告)日：2011-08-03

申请号：EP09713730

申请日：2009-02-11

申请人： MERCK SHARP & DOHME

发明人： COLANDREA VINCENT J ,  HALE JEFFREY J ,  MCCOY JOSHUA G

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P7/06

CPC分类号： C07D491/048