公开(公告)号：EP3330272A1

公开(公告)日：2018-06-06

申请号：EP17201148.8

申请日：2014-04-18

申请人： MERCK SHARP & DOHME CORP.

发明人： Coleman, Paul J. ,  Hartingh, Timothy J. ,  Raheem, Izzat T. ,  Schreier, John ,  Sisko, John T. ,  Wai, John ,  Graham, Thomas ,  Hu, Lihong ,  Peng, Xuanjia

IPC分类号： C07D491/16 ,  C07D471/16 ,  C07D487/16 ,  A61K31/5025 ,  A61K31/5365 ,  A61P31/18

CPC分类号： C07D498/16 ,  A61K31/4985 ,  A61K31/5383 ,  A61K45/06 ,  C07D471/16 ,  C07D487/16 ,  C07D491/16

摘要： The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I):

and pharmaceutically acceptable salts thereof, wherein R 1 -R 8 , A, X and n are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and the Fused Tricyclic Heterocycle Derivatives for use in treating or preventing HIV infection in a subject.