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1.发明公开Novel substituted piperidines and their use as inhibitors of cholesterol synthesis 失效Neue substitutionierte Piperidine and ihre Verwendung als Inhibitoren der Cholesterol-Synthese。
公开(公告)号：EP0468457A1
公开(公告)日：1992-01-29
申请号：EP91112343.8
申请日：1991-07-23
IPC分类号： C07D211/22 , A61K31/445 , A01N43/40
CPC分类号： C07D211/22
摘要： The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
摘要翻译： 本发明涉及一组新的取代的哌啶化合物，其作用是抑制哺乳动物和真菌中胆固醇的合成。
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2.发明公开Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis 失效Neue Piperidylether und -thioether als Inhibitoren der Cholesterol-Biosynthes。
公开(公告)号：EP0468434A1
公开(公告)日：1992-01-29
申请号：EP91112311.5
申请日：1991-07-23
IPC分类号： C07D295/088 , C07D211/46 , C07D211/22 , A61K31/445
CPC分类号： C07D295/088 , C07D211/22 , C07D211/46
摘要： The present invention relates to certain novel piperidyl ethers and thioethers and to pharmaceutical compositions containing these which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
摘要翻译： 本发明涉及某些新颖的哌啶基醚和硫醚以及含有这些的药物组合物，其可用作胆固醇生物合成的抑制剂，并且作为降低有需要的患者的总血清胆固醇的试剂。
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公开(公告)号：EP0304889A3
公开(公告)日：1990-01-24
申请号：EP88113788.9
申请日：1988-08-24
IPC分类号： C07H19/16 , C07H19/167 , C07H19/173 , C07H19/23 , C07D473/00 , C07D473/28 , C07D473/34 , C07D471/04 , C07D487/04 , A61K31/70
CPC分类号： C07D473/00 , C07H19/052 , C07H19/056 , C07H19/16
摘要： This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.
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公开(公告)号：EP0304889B1
公开(公告)日：1996-08-14
申请号：EP88113788.9
申请日：1988-08-24
IPC分类号： C07H19/16 , C07H19/167 , C07H19/173 , C07H19/23 , C07D473/00 , C07D473/28 , C07D473/34 , C07D471/04 , C07D487/04 , A61K31/70
CPC分类号： C07D473/00 , C07H19/052 , C07H19/056 , C07H19/16
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公开(公告)号：EP0304889A2
公开(公告)日：1989-03-01
申请号：EP88113788.9
申请日：1988-08-24
IPC分类号： C07H19/16 , C07H19/167 , C07H19/173 , C07H19/23 , C07D473/00 , C07D473/28 , C07D473/34 , C07D471/04 , C07D487/04 , A61K31/70
CPC分类号： C07D473/00 , C07H19/052 , C07H19/056 , C07H19/16
摘要： This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译： 本发明涉及可用于抑制AdoMet依赖性转甲基化和治疗患有肿瘤或病毒疾病状态的患者的某些佐剂霉素/腺苷衍生物。
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