公开(公告)号：EP1983046A4

公开(公告)日：2009-03-25

申请号：EP07707949

申请日：2007-02-02

申请人： MESSENGERSCAPE CO LTD ,  ORIENTAL YEAST CO LTD

发明人： SAITO TOSHIYUKI ,  MIKAMI YOJI ,  KINUGASA MASAHIRO ,  MORI KAZUYA ,  SUGIMOTO MICHIYO ,  UCHIDA KOJI

IPC分类号： C12N15/00 ,  C12N15/09 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： It is intended to provide a novel method for determining the possibility of lymph node metastasis of breast cancer using a difference of expression level of a specific gene between a human metastatic breast cancer tissue (or cell) and a nonmetastatic breast cancer tissue (or cell) as an index. For this purpose, the method characterized by: (1) measuring the expression level of a gene having a specific base sequence in a human metastatic breast cancer tissue (or cell); (2) measuring the expression level of the gene in a human nonmetastatic breast cancer tissue (or cell); and (3) comparing the measured values of (1) and (2) and determining the possibility of lymph node metastasis of breast cancer based on the difference is provided.

摘要翻译： 本发明旨在提供一种使用人转移性乳腺癌组织（或细胞）和非转移性乳腺癌组织（或细胞）之间特定基因的表达水平差异来确定乳腺癌淋巴结转移可能性的新方法， 作为索引。 为此，所述方法的特征在于：（1）测量人转移性乳腺癌组织（或细胞）中具有特定碱基序列的基因的表达水平; （2）测量人非转移性乳腺癌组织（或细胞）中基因的表达水平; （3）比较（1）和（2）的测量值并基于该差异确定乳腺癌的淋巴结转移的可能性。

公开(公告)号：EP2128621A4

公开(公告)日：2011-05-18

申请号：EP07707909

申请日：2007-02-01

申请人： ORIENTAL YEAST CO LTD

发明人： KINUGASA MASAHIRO ,  SUGIMOTO MICHIYO ,  UCHIDA KOJI

IPC分类号： G01N33/574

CPC分类号： G01N33/57415

摘要： The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2).

公开(公告)号：EP1580264A4

公开(公告)日：2006-03-08

申请号：EP03769965

申请日：2003-10-29

申请人： ORIENTAL YEAST CO LTD ,  RIKEN

发明人： ISHII SHUNSUKE ,  SHINAGAWA TOSHIE ,  UCHIDA KOJI ,  HAYASHI NAOKI

IPC分类号： A01K67/027 ,  C12N15/09 ,  C12N5/10

CPC分类号： A01K67/0275 ,  A01K2217/05

摘要： A target gene-knockdown animal and a disease model animal in which mRNA of an endogenous target gene is disrupted by forming double-stranded RNA of the target gene; a method of constructing such an animal; a double-stranded RNA expression vector to be used in the construction method; and animal cells having this vector transferred thereinto.