专利检索 ap:("METABOLEX, INC.") AND inv:"BLUME, John, E." 第 1 页

1.

发明公开
METHODS AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF DIABETES 审中-公开
标题翻译：方法和试剂糖尿病的诊断与治疗

公开(公告)号：EP1461351A2

公开(公告)日：2004-09-29

申请号：EP02786860.3

申请日：2002-12-02

申请人： METABOLEX, INC.

发明人： JOHNSON, Jeffrey, D. , BLUME, John, E. , PALMA, John, F. , ZHOU, Yun-Ping

IPC分类号： C07H21/04 , C12N15/09 , C12N15/74

CPC分类号： C07K14/47

摘要： Methods and Reagents for Diagnosis and Treatment of DiabetesThe invention relates to methods and reagents for diagnosing and treating diabetes.

2.

发明公开
COMPOSITIONS AND METHODS OF USING HEXOKINASE V 审中-公开
标题翻译：组合物及其使用方法己糖激酶V

公开(公告)号：EP1604036A2

公开(公告)日：2005-12-14

申请号：EP04757980.0

申请日：2004-03-19

申请人： METABOLEX, INC.

发明人： JOHNSON, Jeffrey, D. , GREGOIRE, Francine, M. , SCHWEITZER, Anthony , TERASAWA, Yuko , WILSON, Maria, S. , BLUME, John, E.

IPC分类号： C12Q1/48 , G01N33/68

CPC分类号： G01N33/5008 , C12Q1/485 , G01N33/502 , G01N33/5023 , G01N33/5044 , G01N33/507 , G01N33/5088 , G01N33/5091 , G01N33/6893 , G01N2800/042

摘要： The current invention provides methods of identifying modulators of hexokinase V. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of hexokinase V nucleic acids and proteins.

3.

发明公开
METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DIABETES 审中-公开
标题翻译：治疗和诊断糖尿病的方法和组合物

公开(公告)号：EP1572085A3

公开(公告)日：2005-09-21

申请号：EP03737015.2

申请日：2003-06-10

申请人： METABOLEX, INC.

发明人： JOHNSON, Jeffrey, D. , PALMA, John, F. , SCHWEITZER, Anthony, C. , BLUME, John, E.

IPC分类号： A61K6/00

4.

发明公开
METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DIABETES 审中-公开
标题翻译：方法和组合物诊断糖尿病和BEHANDLUND的

公开(公告)号：EP1572085A2

公开(公告)日：2005-09-14

申请号：EP03737015.2

申请日：2003-06-10

申请人： METABOLEX, INC.

发明人： JOHNSON, Jeffrey, D. , PALMA, John, F. , SCHWEITZER, Anthony, C. , BLUME, John, E.

IPC分类号： A61K6/00

CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04 , G01N2500/10

摘要： The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposion for diabetes.

5.

发明公开
NUCLEIC ACIDS ENCODING A G-PROTEIN COUPLED RECEPTOR INVOLVED IN ISLET CELL SIGNALING 审中-公开
标题翻译： A ON CELL SIGNALING是否涉及G蛋白偶联受体的核酸编码岛

公开(公告)号：EP1506306A2

公开(公告)日：2005-02-16

申请号：EP03710641.6

申请日：2003-01-06

申请人： METABOLEX, INC.

发明人： GREGOIRE, Francine, M. , JOHNSON, Jeffrey, D. , BLUME, John, E.

IPC分类号： C12Q1/00

CPC分类号： C07K14/705

摘要： The invention provides isolated nucleic acid and amino acid sequences of human and murine islet cell G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, methods of screening for modulators of islet cell G-protein coupled receptors and methods of treating mammals with modulators of islet cell G-protein coupled receptor activity.