公开(公告)号：EP0303088B1

公开(公告)日：1992-11-11

申请号：EP88111931.7

申请日：1988-07-25

申请人： MILES INC.

发明人： Dove, George ,  Mitra, Gautam

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07K3/28

CPC分类号： C07K16/1214 ,  A61K38/00

公开(公告)号：EP0303088A2

公开(公告)日：1989-02-15

申请号：EP88111931.7

申请日：1988-07-25

申请人： MILES INC.

发明人： Dove, George ,  Mitra, Gautam

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07K3/28

CPC分类号： C07K16/1214 ,  A61K38/00

摘要： An essentially pure and stabilized antibody preparation comprising IgM antibodies having a purity greater than about 98% by weight and a nucleic acid content of less than about 200 pg per mg IgM. In one embodiment IgM antibodies from a monoclonal source are subjected to ion exchange and size exclusion chromatography at an alkaline pH to yield a purified IgM having a nucleic acid content of less than 10 pg/mg IgM, preferably less than about 4 pg/mg IgM. A highly purified and stabilized preparation of anti Pseudomonas aeruginosa antibodies is disclosed.

摘要翻译： 基本上纯的和稳定的抗体制剂，其包含纯度大于约98重量％且核酸含量小于约200pg / mg IgM的IgM抗体。 在一个实施方案中，来自单克隆来源的IgM抗体在碱性pH下进行离子交换和尺寸排阻色谱以产生核酸含量小于10pg / mg IgM，优选小于约4pg / mg IgM的纯化IgM 。 公开了高度纯化和稳定的抗铜绿假单胞菌抗体制剂。

公开(公告)号：EP0303088A3

公开(公告)日：1989-05-17

申请号：EP88111931.7

申请日：1988-07-25

申请人： MILES INC.

发明人： Dove, George ,  Mitra, Gautam

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07K3/28

CPC分类号： C07K16/1214 ,  A61K38/00

摘要： An essentially pure and stabilized antibody preparation comprising IgM antibodies having a purity greater than about 98% by weight and a nucleic acid content of less than about 200 pg per mg IgM. In one embodiment IgM antibodies from a monoclonal source are subjected to ion exchange and size exclusion chromatography at an alkaline pH to yield a purified IgM having a nucleic acid content of less than 10 pg/mg IgM, preferably less than about 4 pg/mg IgM. A highly purified and stabilized preparation of anti Pseudomonas aeruginosa antibodies is disclosed.