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2.发明授权AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF 失效AZLAKTONFUNKTIONEN HAVING基质，角膜移植及其用途
公开(公告)号：EP0647143B1
公开(公告)日：1998-01-28
申请号：EP93913870.7
申请日：1993-05-13
发明人： CAPECCHI, John, T. , HEILMANN, Steven, M. , KREPSKI, Larry, R. , KWON, Oh-Seung , OLSON, David, B.
IPC分类号： A61L27/00
CPC分类号： C08F8/30 , A61F2/14 , A61F2/142 , A61F2/15 , A61L27/28 , A61L27/34 , A61L27/50 , A61L27/52 , C07C45/71 , C07C49/84 , C08K5/15 , C08L89/00 , C07C49/835
摘要： Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.
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公开(公告)号：EP0710209B1
公开(公告)日：1997-03-19
申请号：EP94921327.6
申请日：1994-06-17
发明人： KWON, Oh-Seung
IPC分类号： B65D83/14
摘要： A device for delivering an aerosol, comprising: a casing member (14), a valve stem (12), and a diaphragm (16). The diaphragm (16) contains a blend of (a) 100 parts by weight of a polyolefin random copolymer of about 80 to about 95 mole percent ethylene and a total of about 5 to about 20 mole percent of 1-butene, and (b) at least 10 parts by weight of a rubber comprising a styrene-ethylene/butylene-styrene block copolymer based on 100 parts by weight of polyolefin. The styrene-ethylene/butylene-styrene block copolymer is substantially uniformly dispersed within the polyolefin. The blend preferably has a Shore A hardness of 65 to 85.
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4.发明授权SUPPORTS HAVING AZLACTONE-FUNCTIONAL SURFACES, ADDUCT SUPPORTS, AND METHODS OF PREPARING SAME 失效Azlactonefunctional支撑区域，聚集载体和方法及其生产
公开(公告)号：EP0644904B1
公开(公告)日：1997-07-16
申请号：EP93911302.3
申请日：1993-05-13
发明人： GAGNON, David, R. , COLEMAN, Patrick, L. , DRTINA, Gary, J. , KWON, Oh-Seung , LYONS, Christopher, S. , MILBRATH, Dean, S. , RASMUSSEN, Jerald, K. , STAHL, Julie, B.
IPC分类号： C08F226/06
CPC分类号： C08F226/06 , A61L33/0011 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J2220/54 , C07K17/08 , C08F8/30 , C12N11/08 , G01N33/54353 , Y10T428/249953 , Y10T428/249954 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249991
摘要： Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, cross-linking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.
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5.发明公开AZLACTONE-FUNCTIONAL SUBSTRATES, CORNEAL PROSTHESES, AND MANUFACTURE AND USE THEREOF 失效AZLAKTONFUNKTIONEN HAVING基质，角膜移植及其用途。
公开(公告)号：EP0647143A1
公开(公告)日：1995-04-12
申请号：EP93913870.0
申请日：1993-05-13
发明人： CAPECCHI, John, T. , HEILMANN, Steven, M. , KREPSKI, Larry, R. , KWON, Oh-Seung , OLSON, David, B.
CPC分类号： C08F8/30 , A61F2/14 , A61F2/142 , A61F2/15 , A61L27/28 , A61L27/34 , A61L27/50 , A61L27/52 , C07C45/71 , C07C49/84 , C08K5/15 , C08L89/00 , C07C49/835
摘要： Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.
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6.发明公开SUPPORTS HAVING AZLACTONE-FUNCTIONAL SURFACES, ADDUCT SUPPORTS, AND METHODS OF PREPARING SAME 失效Azlactonefunctional支撑区域，聚集载体和方法及其生产。
公开(公告)号：EP0644904A1
公开(公告)日：1995-03-29
申请号：EP93911302.0
申请日：1993-05-13
发明人： GAGNON, David, R. , COLEMAN, Patrick, L. , DRTINA, Gary, J. , KWON, Oh-Seung , LYONS, Christopher, S. , MILBRATH, Dean, S. , RASMUSSEN, Jerald, K. , STAHL, Julie, B.
CPC分类号： C08F226/06 , A61L33/0011 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J2220/54 , C07K17/08 , C08F8/30 , C12N11/08 , G01N33/54353 , Y10T428/249953 , Y10T428/249954 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249991
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