公开(公告)号：EP1008349A4

公开(公告)日：2004-01-14

申请号：EP98938967

申请日：1998-08-24

申请人： MITSUBISHI PHARMA CORP ,  LTT BIO PHARMA CO LTD

发明人： EGI YASUHIRO ,  KUBO YOSHIJI ,  INOUE SATORU ,  KIDO HIDEAKI ,  NISHIKAWA MASAKUNI ,  HAYASHI KAZUTAKA

IPC分类号： A61K31/557 ,  A61K31/5575 ,  A61K38/18 ,  A61K45/06

CPC分类号： A61K31/727 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/70 ,  A61K31/715 ,  A61K38/1825 ,  A61K45/06 ,  A61K31/505 ,  A61K2300/00

摘要： An angiogenesis promoter containing a compound of the following formula (I) wherein R is acyl, R is alkyl, R and R are the same or different and each is hydrogen atom or hydroxy protecting group and R is alkyl, as an active ingredient. This compound itself not only has an angiogenesis promoting effect but also potentiates the angiogenic effect by a drug (e.g., b-FGF) having such effect. Therefore, it can express the angiogenesis promoting effect more effectively in the ischemic tissues and the site under different disease state, where b-FGF has locally increased.