公开(公告)号：EP0983257A1

公开(公告)日：2000-03-08

申请号：EP98908949.5

申请日：1998-03-04

申请人： Monsanto Company

发明人： BECKER, Daniel, P. ,  VILLAMIL, Clara, I. ,  LI, Madeleine, H. ,  BOEHM, Terri, L. ,  GETMAN, Daniel, P. ,  McDONALD, Joseph, J. ,  DeCRESCENZO, Gary, A.

IPC分类号： C07D309/08 ,  C07D211/54 ,  C07D213/64 ,  C07D401/06 ,  C07D407/12 ,  C07D413/12 ,  C07D405/12 ,  A61K31/35 ,  A61K31/445

CPC分类号： C07D213/30 ,  C07C317/22 ,  C07C317/44 ,  C07C323/65 ,  C07D207/16 ,  C07D211/62 ,  C07D213/82 ,  C07D295/15

摘要： An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-cycloamino hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

公开(公告)号：EP0977745A1

公开(公告)日：2000-02-09

申请号：EP98911479.8

申请日：1998-03-04

申请人： MONSANTO COMPANY

发明人： GETMAN, Daniel, P. ,  BECKER, Daniel, P. ,  BARTA, Thomas, E. ,  VILLAMIL, Clara, I. ,  HOCKERMAN, Susan, L. ,  BEDELL, Louis, J. ,  LI, Madeleine, H. ,  FRESKOS, John, N. ,  HEINTZ, Robert, M. ,  McDONALD, Joseph, J. ,  DeCRESCENZO, Gary, A.

IPC分类号： C07D295/14 ,  A61K31/535

CPC分类号： C07C311/46 ,  C07D213/42 ,  C07D213/82 ,  C07D295/13 ,  C07D309/12 ,  C07D417/12

摘要： A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

摘要翻译： 公开了尤其抑制基质金属蛋白酶活性的硫代芳基磺酰胺异羟肟酸化合物，该方法包括给予具有与病理基质金属蛋白酶活性有关的病症的基质的MMP抑制有效量的预期硫代芳基磺酰胺异羟肟酸化合物 。

公开(公告)号：EP0983258A1

公开(公告)日：2000-03-08

申请号：EP98908964.4

申请日：1998-03-04

申请人： MONSANTO COMPANY

发明人： BARTA, Thomas, E. ,  BECKER, Daniel, P. ,  VILLAMIL, Clara, I. ,  FRESKOS, John, N. ,  MISCHKE, Brent, V. ,  MULLINS, Patrick, B. ,  HEINTZ, Robert, M. ,  GETMAN, Daniel, P. ,  McDONALD, Joseph, J.

IPC分类号： C07D309/08 ,  C07D211/54 ,  C07D213/64 ,  C07D401/06 ,  C07D407/12 ,  C07D413/12 ,  C07D405/12 ,  A61K31/35 ,  A61K31/445

CPC分类号： C07D213/30 ,  C07C317/22 ,  C07C317/44 ,  C07C323/65 ,  C07D207/16 ,  C07D211/62 ,  C07D213/82 ,  C07D295/15

摘要： An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as is a treatment process that comprises administering a contemplated N-hydroxy sulfonyl butanamide compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metall protease activity.

摘要翻译： 公开了尤其抑制基质金属蛋白酶活性的N-羟基磺酰基丁酰胺化合物，该方法包括给予MMP酶抑制有效量的预期N-羟基磺酰基丁酰胺化合物至具有与病理学基质相关病症的宿主 金属蛋白酶活性。