专利检索 ap:("MYRIAD GENETICS, INC.") AND inv:"YUNGAI, Ashantai J." 第 1 页

1.

发明公开
COMPOUNDS FOR ALZHEIMER'S DISEASE 有权
标题翻译： CONNECTIONS抗阿尔茨海默氏病

公开(公告)号：EP1809601A2

公开(公告)日：2007-07-25

申请号：EP05802834.1

申请日：2005-10-04

申请人： MYRIAD GENETICS, INC.

发明人： SLADE, Rachel , KLIMOVA, Yevgeniya , HALTER, Robert J. , YUNGAI, Ashantai J. , WEINER, Warren S. , WALTON, Ruth J. , WILLARDSEN, Jon Adam , ANDERSON, Mark B. , ZAVITZ, Kenton

IPC分类号： C07D209/04 , A61K31/404

CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D417/04

摘要： The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(=O)OH, -L-CH=CHC(=O)OH, -L-C(=O)NH2, -L-C(=O)NH(C1-3 alkyl), -L-C(=O)N(C1-3 alkyl)2, -L-S(=O)2(C1-3alkyl), -L-S(=O)2NH2, -L-S(=O)2N(C1-3 alkyl)2, -L-S(=O)2NH(C1-3 alkyl), -L-C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L-NHC(=O)ORo, -L-C(=O)NHRo, -L-NH(C=O)NHRo, -L-C(=O)N(Ro)2, -L-NH(C=O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.