公开(公告)号：EP3230472A4

公开(公告)日：2018-06-13

申请号：EP15866475

申请日：2015-12-08

申请人： MYRIAD GENETICS INC ,  TESARO INC

发明人： WILCOXEN KEITH ,  LANCHBURY JERRY ,  GUTIN ALEXANDER ,  TIMMS KIRSTEN ,  ABKEVICH VICTOR ,  WANG YAN

IPC分类号： C12Q1/68 ,  A61K31/416 ,  G06F19/22

CPC分类号： C12Q1/6886 ,  A61K31/454 ,  C12Q2600/106 ,  C12Q2600/158

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature to predict response to niraparib. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature to predict response to niraparib are provided.