公开(公告)号：EP3035956A2

公开(公告)日：2016-06-29

申请号：EP14837376.4

申请日：2014-08-20

申请人： MacroGenics, Inc.

发明人： MOORE, Paul A. ,  LI, Jonathan ,  CHEN, Francine Zhifen ,  JOHNSON, Leslie S. ,  SHAH, Kalpana ,  BONVINI, Ezio

IPC分类号： A61K39/00 ,  C12P21/08 ,  C07K16/00

摘要： The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a "gpA33 x CD3 bi-specific monovalent diabody"). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc domain ("bi-specific monovalent Fc diabodies") and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 ( i.e ., a "gpA33 x CD3 bi-specific monovalent Fc diabody"). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.

摘要翻译： 本发明涉及双特异性双抗体的单价确实包含两条多肽链和其中在gpA33（即，“gpA33 X CD3双抗体的表位具有特异性的CD3处的表位特异性针对至少一个结合位点和一个结合位点 具体单价双体“）。 因此，本发明涉及双特异性单价双抗体做了包括免疫球蛋白Fc结构域（“双特异性单价的Fc双抗体”）的和由三个多肽链和其具有特异于至少一个结合位点在gpA33的表位和 特异于CD3的表位的结合位点（即，一个“gpA33 X CD3双特异性单价的Fc双抗体”）。 所述双特异性单价双抗体和本发明的双特异性单价的Fc抗体是能够同时结合gpA33和CD3的。 本发明涉及药物组合物的确含有寻求双特异性单价双体或寻求双特异性单价的Fc双体。 本发明另外涉及用于在癌症和其它疾病和病症的治疗中使用的搜索双抗体的方法。

公开(公告)号：EP3035956B1

公开(公告)日：2020-07-22

申请号：EP14837376.4

申请日：2014-08-20

申请人： MacroGenics, Inc.

发明人： MOORE, Paul A. ,  LI, Jonathan ,  CHEN, Francine Zhifen ,  JOHNSON, Leslie S. ,  SHAH, Kalpana ,  BONVINI, Ezio

IPC分类号： C07K16/28 ,  A61K39/00