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1.发明公开FUSION PROTEIN COMPRISING AXL AND COMPOSITION FOR TREATING CANCER COMPRISING SAME 有权FUSIONSPROTEIN麻醉师AXL SOWIE ZUSAMMENSETZUNG ZUR KREBSBEHANDLUNG DAMIT
公开(公告)号：EP2894169A1
公开(公告)日：2015-07-15
申请号：EP13836076.3
申请日：2013-09-06
申请人： Macrogen Inc. , SNU R&DB Foundation , Catholic University Industry-Academic Cooperation Foundation
CPC分类号： C12Q1/6886 , C07K14/4703 , C07K14/71 , C07K2319/00 , C12N9/12 , C12Q2600/136
摘要： Provided is a fusion protein comprising AXL receptor tyrosine kinase (AXL protein) and MAP3K12 binding inhibitory protein 1 (MBIP protein), a composition for diagnosing a cancer comprising a substance interacting with the fusion protein, a method of providing information for diagnosing a cancer using the fusion protein, a composition for preventing and/or treating a cancer comprising an inhibitor against the fusion protein, and a method for screening an anticancer agent using the fusion protein.
摘要翻译： 提供了包含AXL受体酪氨酸激酶（AXL蛋白）和MAP3K12结合抑制蛋白1（MBIP蛋白）的融合蛋白，用于诊断包含与融合蛋白相互作用的物质的癌症的组合物，提供用于诊断癌症的信息的方法 融合蛋白，用于预防和/或治疗包含抗融合蛋白的抑制剂的癌症的组合物，以及使用该融合蛋白筛选抗癌剂的方法。
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2.发明公开FUSION PROTEIN COMPRISING C-TERMINAL DOMAIN OF RET PROTEIN AND USE THEREOF AS A DIAGNOSING MARKER 审中-公开与RET蛋白的C端结构域和其作为诊断标志物的融合蛋白
公开(公告)号：EP2773673A1
公开(公告)日：2014-09-10
申请号：EP12845116.8
申请日：2012-10-31
申请人： Macrogen Inc.
发明人： JU, Young-Seok , SEO, Jeong-Sun , KIM, Eun-Hee
CPC分类号： C12N9/96 , C07K2319/03 , C12N9/12 , C12Q1/6886 , C12Q2600/156
摘要： A fusion protein including N-terminal domain of a fusion partner at N-terminal and C-terminal domain of RET protein at C-terminal, a fusion gene encoding the fusion protein, and a use of the fusion protein or the fusion gene as a diagnosing marker for a cancer, are provided.
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公开(公告)号：EP2894169B1
公开(公告)日：2018-05-23
申请号：EP13836076.3
申请日：2013-09-06
申请人： Macrogen, Inc.
CPC分类号： C12Q1/6886 , C07K14/4703 , C07K14/71 , C07K2319/00 , C12N9/12 , C12Q2600/136
摘要： Provided is a fusion protein comprising AXL receptor tyrosine kinase (AXL protein) and MAP3K12 binding inhibitory protein 1 (MBIP protein), a composition for diagnosing a cancer comprising a substance interacting with the fusion protein, a method of providing information for diagnosing a cancer using the fusion protein, a composition for preventing and/or treating a cancer comprising an inhibitor against the fusion protein, and a method for screening an anticancer agent using the fusion protein.
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