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公开(公告)号：EP0215662A2
公开(公告)日：1987-03-25
申请号：EP86307088.4
申请日：1986-09-15
摘要： Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of proteases originating from microorganisms.
Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of a protease originating from a microorganism which protease is chemically modified by one of the following procedures:
a) coupling with a saccharide,
b) introduction of a hydrophobic polymeric group,
c) alteration of electric charge of the protein surface,
d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,
e) formation of dimer or oligomer by cross-linking of protease molecules,
f) conjugation with a synthetic polycation,
g) conjugation with a synthetic polyanion, and
h) combination of the above-mentioned procedures.
Microorganism protease is chemically modified by one of the following procedures:
a) coupling with a saccharide,
b) introduction of a hydrophobic polymeric group,
c) alteration of electric charge of the protein surface,
d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,
e) formation of dimer or oligomer by cross-linking of protease molecules,
f) conjugation with a synthetic polycation,
g) conjugation with a synthetic polyanion, and
h) combination of the above-mentioned procedures.-
公开(公告)号：EP0215662A3
公开(公告)日：1988-10-19
申请号：EP86307088
申请日：1986-09-15
摘要： Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of proteases originating from microorganisms. Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of a protease originating from a microorganism which protease is chemically modified by one of the following procedures:
a) coupling with a saccharide, b) introduction of a hydrophobic polymeric group, c) alteration of electric charge of the protein surface, d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000, e) formation of dimer or oligomer by cross-linking of protease molecules, f) conjugation with a synthetic polycation, g) conjugation with a synthetic polyanion, and h) combination of the above-mentioned procedures. Microorganism protease is chemically modified by one of the following procedures:
a) coupling with a saccharide, b) introduction of a hydrophobic polymeric group, c) alteration of electric charge of the protein surface, d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000, e) formation of dimer or oligomer by cross-linking of protease molecules, f) conjugation with a synthetic polycation, g) conjugation with a synthetic polyanion, and h) combination of the above-mentioned procedures.
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