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    VENTRICULAR ASSIST DEVICE
    1.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4252828A2

    公开(公告)日：2023-10-04

    申请号：EP23189149.0

    申请日：2022-08-30

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKI, Gad ,  TROSHIN, Victor ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  ROZENFELD, Avi

    IPC分类号： A61M60/865

    摘要： Apparatus for use with a percutaneous ventricular assist device (20) that comprises a self-expandable pump head (27) and that is configured to be delivered to a subject's left ventricle using a delivery catheter (143), while the pump head (27) is disposed in a radially-constrained configuration within the delivery catheter (143), the apparatus comprising: packaging (270) for the ventricular assist device, the packaging (270) being shaped to define: a pump-head chamber (274) in which the pump head (274) is packaged in a non-radially constrained configuration; and a surface (284) that is slanted downwards; and a catheter-securement piece (276) configured to secure a distal end of the delivery catheter to the surface (284) that is slanted downwards, such that the distal end of the catheter (273) is oriented in a downwards slant, the packaging (270) being configured such that the pump head (27) is configured to be radially constrained by being retracted into the distal end of the delivery catheter (143), while the distal end of the delivery catheter (143) is secured to the surface (284) that is slanted downwards.

    VENTRICULAR ASSIST DEVICE
    2.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4218900A1

    公开(公告)日：2023-08-02

    申请号：EP23159725.3

    申请日：2022-03-07

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKY, Gad ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  TROSHIN, Victor

    IPC分类号： A61M60/13 ,  A61M60/237 ,  A61M60/414 ,  A61M60/808 ,  A61M60/81 ,  A61M60/888 ,  A61M60/865 ,  A61M60/857

    摘要： An apparatus, comprising: a ventricular assist device (20) comprising: a frame (34) comprising struts that define a plurality of cells, the frame (34) being configured such that, in a non-radially-constrained configuration of the frame (34), the frame (34) comprises a generally cylindrical central portion (38); a pump-outlet tube (24) that defines one or more blood outlet openings (109), a portion of the pump-outlet tube (24) being disposed outside the frame (34) and coupled to the generally cylindrical central portion (38) of the frame (34), such that the portion of the pump-outlet tube (24) conforms with a structure of struts of the frame; an inner lining (39) coupled to an inside of the generally cylindrical central portion (38) of the frame (34), such as to provide the generally cylindrical portion (38) of the frame (34) with a smooth inner surface; an impeller (50) disposed at least partially inside the generally cylindrical central portion (38) of the frame (34) and configured to pump blood through the tube (24) and out of the one of more blood outlet openings (109); and a protective braid (150) disposed over a distal portion (40) of the frame (34) and configured to block structures from the subject's left ventricle from entering into the frame (34), a proximal end of the protective braid (150) being embedded between the pump-outlet tube (24) and the inner lining (39), such that, during crimping of the frame (34), the protective braid (150) becomes crimped with the pump-outlet tube (24) and the inner lining (39), thereby preventing the protective braid (150) from moving with respect to pump-outlet tube (24) or the inner lining (39).

    VENTRICULAR ASSIST DEVICE
    4.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4218898A1

    公开(公告)日：2023-08-02

    申请号：EP23159721.2

    申请日：2022-03-07

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKY, Gad ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  TROSHIN, Victor

    IPC分类号： A61M60/13 ,  A61M60/237 ,  A61M60/414 ,  A61M60/808 ,  A61M60/81 ,  A61M60/888 ,  A61M60/865 ,  A61M60/857

    摘要： A method, comprising: manufacturing a housing for an impeller (50) of a blood pump by: treating a frame (34) in order to enhance bonding between an inner surface of the frame (34) and an inner lining (39); subsequently, coupling the inner lining (39) to the inner surface of the frame (34) along at least a portion of a central cylindrical portion of the frame (34), the central cylindrical portion of the frame (34) including struts that define a generally cylindrical shape; subsequent to coupling the inner lining (39) to the inner surface of the frame (34) along at least a portion of the central cylindrical portion of the frame (34): placing a mandrel inside the inner lining (39); placing a portion of an elongate tube (24) around at least a portion of the frame (34), the elongate tube including a proximal portion that defines at least one blood outlet opening (109); while the portion of the elongate tube (24) is disposed around at least the portion of the frame (34), heating the inner lining (39), the frame (34) and the portion of the elongate tube (24), via the mandrel; and while heating the inner lining (39), the frame (34), and the portion of the elongate tube (24), applying pressure from outside the portion of the elongate tube (24), such as to cause the portion of the elongate tube (24) to become coupled to the frame (34).

    VENTRICULAR ASSIST DEVICE
    5.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4252825A2

    公开(公告)日：2023-10-04

    申请号：EP23189145.8

    申请日：2022-08-30

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKI, Gad ,  TROSHIN, Victor ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  ROZENFELD, Avi

    IPC分类号： A61M60/865

    摘要： An apparatus comprising: a pump-outlet tube (24) configured to traverse an aortic valve of a subject, such that a proximal end of the pump-outlet tube (24) is disposed within an aorta of the subject and a distal end of the pump-outlet tube (24) is disposed within a left ventricle of the subject;_an impeller (50) configured to be disposed within the left ventricle within the pump-outlet tube (24), and to pump blood through the pump-outlet tube (24); a frame (34) disposed around the impeller, the frame (34) defining a cylindrical portion (38) and a proximal conical portion (36) that is disposed proximally to the cylindrical portion (38) and that widens from a proximal end of the frame (34) to the cylindrical portion (38) of the frame (34) ; at least one optical fiber (228), a proximal end of which is configured to be disposed outside a body of the subject and a distal portion of which is coupled to the proximal conical portion (36) of the frame (34) such that a distal end (230) of the optical fiber (228) extends to outside the pump-outlet tube (24) and is configured to be disposed in direct fluid communication with left-ventricular bloodstream of the subject outside the pump-outlet tube (24).

    VENTRICULAR ASSIST DEVICE
    6.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4218899A1

    公开(公告)日：2023-08-02

    申请号：EP23159724.6

    申请日：2022-03-07

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKY, Gad ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  TROSHIN, Victor

    IPC分类号： A61M60/13 ,  A61M60/237 ,  A61M60/414 ,  A61M60/808 ,  A61M60/81 ,  A61M60/888 ,  A61M60/865 ,  A61M60/857

    摘要： A method, comprising: manufacturing a housing for an impeller (50) of a blood pump by: placing a mandrel inside an inner lining (39), with a central cylindrical portion of a frame (34) disposed around the inner lining (39), the central cylindrical portion of the frame (34) including struts that define a generally cylindrical shape, wherein the mandrel is shorter than a length of the inner lining (39); placing a portion of an elongate tube (24) around at least a portion of the frame (34), the elongate tube (24) including a proximal portion that defines at least one blood outlet opening; while the portion of the elongate tube (24) is disposed around at least the portion of the frame (34), heating the inner lining (39), the frame (34) and the portion of the elongate tube (24), via the mandrel; and while heating the inner lining (39), the frame (34), and the portion of the elongate tube (24), applying pressure from outside the portion of the elongate tube (24), such as to cause the portion of the elongate tube (24) to become coupled to the frame (34).

    VENTRICULAR ASSIST DEVICE
    7.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4218897A1

    公开(公告)日：2023-08-02

    申请号：EP23159720.4

    申请日：2022-03-07

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKY, Gad ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  TROSHIN, Victor

    IPC分类号： A61M60/13 ,  A61M60/237 ,  A61M60/414 ,  A61M60/808 ,  A61M60/81 ,  A61M60/888 ,  A61M60/865 ,  A61M60/857

    摘要： An apparatus, comprising: a left-ventricular assist device (20) comprising: an impeller (50) configured to be placed inside a left ventricle of a subject and to pump blood from the left ventricle to an aorta of the subject, by rotating; a frame (34) disposed around the impeller; anda pump-outlet tube (24) configured to traverse an aortic valve of the subject, such that a proximal portion of the tube is disposed within the subject's aorta and a distal portion (46) of the pump-outlet tube is disposed within the subject's left ventricle, the distal portion of the pump-outlet tube (24) extending to a distal end of the frame (34) and defining more than 10 blood-inlet openings (108) that are sized such as (a) to allow blood to flow from the subject's left ventricle into the tube (24) and (b) to block structures from the subject's left ventricle from entering into the frame (34), wherein a porosity of the distal portion (46) of the pump-outlet tube (24), which defines the blood-inlet openings (108), is lower within a proximal region (46P) of the distal portion of the pump-outlet tube (24) than within a distal region (46D) of the distal portion (46) of the pump-outlet tube (24) that is distal to the proximal region (46P).

    VENTRICULAR ASSIST DEVICE
    8.
    发明公开
    VENTRICULAR ASSIST DEVICE 审中-公开

    公开(公告)号：EP4252827A2

    公开(公告)日：2023-10-04

    申请号：EP23189148.2

    申请日：2022-08-30

    申请人： Magenta Medical Ltd.

    发明人： TUVAL, Yosi ,  LUBINSKI, Gad ,  TROSHIN, Victor ,  ZEMER HAREL, Hagit ,  FRIEDLAND, Ori ,  ROSENBLUM, Daniel ,  ROZENFELD, Avi

    IPC分类号： A61M60/865

    摘要： An apparatus comprising: a ventricular assist device (20) comprising: an axial shaft (92); an impeller (50) disposed on the axial shaft (92), the impeller (50) being configured to pump blood; a frame (34) disposed around the impeller; a distal thrust bearing (260) disposed within the frame (34), the distal end of the axial shaft (92) being configured to engage with the distal thrust bearing (260) such as to prevent the axial shaft (92) from undergoing axial motion in response to variations in the pressure gradient against which the impeller (50) pumps blood; and a plurality of connecting struts (264) extending radially inwardly from the frame (34) to the distal thrust bearing (260) and coupling the thrust bearing (260) to the frame (34), the frame (34) and the connecting struts (264) being formed as a single integral body.