-
公开(公告)号:EP2340253A2
公开(公告)日:2011-07-06
申请号:EP09789384.6
申请日:2009-09-29
申请人: Mallinckrodt Inc.
发明人: HUDSON, Edmund, C. , TERAMURA, Douglas , GROTE, Christopher, W. , THOMASSON, Catherine, E. , CANTRELL, Gary, L.
IPC分类号: C07D489/12
CPC分类号: C07D489/12
摘要: The present invention is generally directed to a process for the preparation of a ketomorphinan comprising maintaining a ketone group as unprotected and performing reductive amination using a hydrogen source and a catalyst.