公开(公告)号：EP1303387B1

公开(公告)日：2006-06-28

申请号：EP01931299.0

申请日：2001-05-11

申请人： Matregen Corp.

发明人： Dalton, Paul D. ,  Shoichet, Molly S.

IPC分类号： B29C41/04 ,  B29C41/50 ,  B29L23/00 ,  A61K9/00

CPC分类号： A61K9/0092 ,  A61B17/1128 ,  B29C37/006 ,  B29C39/006 ,  B29C39/08 ,  B29C41/042 ,  B29C41/50 ,  B29K2105/0014 ,  B29K2105/04 ,  B29L2023/00 ,  B29L2031/753 ,  Y10T428/1352 ,  Y10T428/139

摘要： A variety of hollow structures with unique morphologies were manufactured with a rotational spinning technique. Phase separation of soluble solutions was induced within a filled mold as it was being rotated about one of its axis. As phase-separation occurs within this rotating mold, the increase in density of one phase results in sediment at the periphery under centrifugal forces. After or during sedimentation, gelation of the phase-separated particles fixes the tube morphology and the solvent remains in the center of the mold. The solvent is removed from the mold resulting in a tube. By controlling the rotational speed and the formulation chemistry, the tube dimensions and wall morphology can be manipulated. This technique offers a new approach to the manufacture of polymeric tubes. It requires small quantities of starting material, permits multi- layering of tubes, is applicable to diverse polymers and can result in highly diffusive hollow structures while maintaining good mechanical strength.