公开(公告)号：EP3137062A1

公开(公告)日：2017-03-08

申请号：EP15786695.5

申请日：2015-04-28

申请人： Matripharm Inc.

发明人： MATEESCU, Mircea-Alexandru ,  LE, Tien Canh

IPC分类号： A61K9/26 ,  A61K47/04 ,  A61K47/36 ,  A61P29/00 ,  A61P3/10

CPC分类号： A61K9/2054 ,  A61K9/2059 ,  A61K31/155 ,  A61K31/606 ,  A61K47/36

摘要： The present document describes a dosage form for delivery of an active ingredient comprising: a first carboxylated polymer having carboxyl groups, having a degree of substitution of at least 0.2, a molecular weight of at least 200 kDa, and at least 30% of said carboxyl groups being complexed with a divalent cation; alone or in a co-complex with at least one of a) a control release polymer chosen from an insoluble polymer or a polymer having a reduced water solubility at 30° C., and a soluble polymer; and b) a second carboxylated polymer having carboxyl groups complexed with a divalent cation. The document also describes processes of making a carboxylated polymer having carboxyl groups, having a degree of substitution of at least 0.2, a molecular weight of at least 200 kDa, and at least 30% of said carboxyl groups being complexed with a divalent cation, and an inclusion complex, a co-complex, or both comprising the same.

摘要翻译： 本文献描述了一种剂型，其用于递送活性成分，其包括：具有第一羧化聚合物的羧基基团，具有一个度至少为0.2，分子量至少为200kDa的的取代，以及所述羧基的至少30％的 基团络合与二价阳离子; 单独使用或在共络合物的至少一个）从水不溶性聚合物或具有在30℃下具有降低了水溶解性，和可溶性聚合物的聚合物中选择的控制释放聚合物; 和b）具有与二价阳离子络合的羧基基团的第二羧化聚合物。 所以该文档描述了制备羧化聚合物具有羧基，聚合度至少0.2，至少200 kDa的分子量，并且所述羧基基团的至少30％的取代的与二价阳离子络合的工序，和 在包合物，共复杂，或两者都包括相同。