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1.发明授权RECONSTRUCTED HUMAN MARINER TRANSPOSON CAPABLE OF STABLE GENE TRANSFER INTO CHROMOSOMES IN VERTEBRATES 有权重建人类MARINER转用于染色体SUITABLE脊椎动物稳定的基因转移
公开(公告)号：EP1869193B1
公开(公告)日：2008-11-26
申请号：EP06723936.8
申请日：2006-03-31
发明人： MISKEY, Csaba , IVICS, Zoltan
摘要： The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further refers to this transposase and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or IR/DRs). Furthermore, applications of this gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
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2.发明公开RECONSTRUCTED HUMAN MARINER TRANSPOSON CAPABLE OF STABLE GENE TRANSFER INTO CHROMOSOMES IN VERTEBRATES 有权重建人类MARINER转用于染色体SUITABLE脊椎动物稳定的基因转移
公开(公告)号：EP1869193A1
公开(公告)日：2007-12-26
申请号：EP06723936.8
申请日：2006-03-31
发明人： MISKEY, Csaba , IVICS, Zoltan
摘要： The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further refers to this transposase and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or IR/DRs). Furthermore, applications of this gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
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3.发明公开HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY 有权多动版DES TRANSPOSASEPROTEINS DES睡袋美容TRANSPOSONSYSTEMS
公开(公告)号：EP2160461A2
公开(公告)日：2010-03-10
申请号：EP08773780.5
申请日：2008-06-30
发明人： IZSVAK, Zsuzsanna , IVICS, Zoltan , MATES, Lajos , MANOJ, Namitha , JUDIS, Carmen-Anisia , KATZER, Andrea
CPC分类号： C12N9/1241 , A61K38/45 , A61K48/00 , A61K48/0066 , C12N9/22 , C12N15/90 , C12N2800/90 , C12Y207/07
摘要： The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using these hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB) and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or RSDs). Furthermore, applications of these transposase variants, the transpsoson, or the gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping), mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
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4.发明授权HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY 有权TRANSPOSASEPROTEINS的的过度活动类型睡美人，转座子
公开(公告)号：EP2160461B1
公开(公告)日：2012-08-08
申请号：EP08773780.5
申请日：2008-06-30
发明人： IZSVAK, Zsuzsanna , IVICS, Zoltan , MATES, Lajos , MANOJ, Namitha , JUDIS, Carmen-Anisia , KATZER, Andrea
CPC分类号： C12N9/1241 , A61K38/45 , A61K48/00 , A61K48/0066 , C12N9/22 , C12N15/90 , C12N2800/90 , C12Y207/07
摘要： The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using these hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB) and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or RSDs). Furthermore, applications of these transposase variants, the transpsoson, or the gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping), mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
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