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    IMPROVED PREPARATION OF VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3
    3.
    发明公开
    IMPROVED PREPARATION OF VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3 审中-公开
    改进的制备疫苗对3型链球菌肺炎的作用

    公开(公告)号：EP3231810A1

    公开(公告)日：2017-10-18

    申请号：EP16165694.7

    申请日：2016-04-15

    申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Vaxxilon AG

    发明人： SEEBERGER, Peter H. ,  PEREIRA, Claney Lebev ,  PARAMESWARAPPA, Sharavathi Guddehalli ,  CALOW, Adam Daniel James ,  MENOVA, Petra ,  BAEK, Ju Yuel

    IPC分类号： C07H1/00 ,  C07H3/06

    CPC分类号： C07H1/00 ,  C07H3/06

    摘要： The present invention relates to the preparation of a synthetic tetrasaccharide representing part of the repeating unit of the Streptococcus pneumoniae type 3 capsular polysaccharide as well as conjugates thereof. Said conjugates are particularly useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae type 3. The disclosed synthetic method has the huge advantages over the state of the art synthetic methods that intermediate products are crystalline, coupling reaction yields are higher, less reaction steps are required and purification of intermediate products is easier.

    摘要翻译： 本发明涉及代表肺炎链球菌3型荚膜多糖的重复单元的一部分的合成四糖的制备及其缀合物。 所述缀合物对于预防和/或治疗与肺炎链球菌相关的疾病，并且更具体地说与肺炎链球菌3型相关的疾病特别有用。所公开的合成方法具有超过现有技术合成方法的巨大优点，即中间产物是 结晶，偶联反应收率更高，需要较少的反应步骤并且中间产物的纯化更容易。