公开(公告)号：EP2211905A1

公开(公告)日：2010-08-04

申请号：EP08843028.5

申请日：2008-10-24

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： ZYCHLINSKY, Arturo ,  MEISSNER, Felix ,  MOLAWI, Kaaweh ,  MEYER, Thomas

IPC分类号： A61K39/395 ,  A61P25/28

CPC分类号： A61K38/1709 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K38/00 ,  A61K38/1793 ,  C07K14/54 ,  C07K14/545 ,  C12N9/0089 ,  C12N9/6475

摘要： The present invention relates to a method for treating, preventing or ameliorating a chronic neurodegenerative disorder, in particular progressive muscular atrophy (PMA), said method comprising administering to a subject in need of such a treatment, prevention or amelioration a specific inhibitor of a caspase l-dependent cytokine. Also specific inhibitors of a caspase l-dependent cytokine for treating, preventing or ameliorating a neurodegenerative disorder, in particular PMA, are disclosed herein. Furthermore, the present invention provides for the use of (a) specific inhibitor(s) of a caspase l-dependent cytokine in the medical or pharmaceutical intervention of neurodegenerative disorders. In particular said cytokine to be inhibited is selected from the group consisting of interleukin-1 (IL-1 ), interleukin-18 (IL-18), interleukin-33 and interferon γ (IFN-γ; interferon-gamma) and most preferably said inhibitor to be employed in context of this invention is a human interleukin-1 receptor antagonist (IL-1 Ra), like anakinra.

公开(公告)号：EP4274847A1

公开(公告)日：2023-11-15

申请号：EP22707084.4

申请日：2022-02-17

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： TILLEY, Dorothea, Ogmore ,  ZYCHLINSKY, Arturo ,  HERZIG, Alf

IPC分类号： C07K16/18 ,  G01N33/68

公开(公告)号：EP3711084A1

公开(公告)日：2020-09-23

申请号：EP18799787.9

申请日：2018-11-14

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： MEISSNER, Felix ,  MANN, Matthias ,  MEIER, Florian ,  VIRREIRA WINTER, Sebastian ,  ZYCHLINSKY, Arturo

IPC分类号： H01J49/00 ,  G01N33/68

公开(公告)号：EP2561367A1

公开(公告)日：2013-02-27

申请号：EP11720409.9

申请日：2011-04-21

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： ZYCHLINSKY, Arturo ,  RAHAMATHULLAH, Abdul, Hakkim ,  BRINKMANN, Volker ,  VOLL, Reinhard

IPC分类号： G01N33/68

CPC分类号： G01N33/6875 ,  G01N33/564 ,  G01N33/6893 ,  G01N2800/104

摘要： The present invention relates to means and methods for identifying an increased risk of systemic lupus erythematosus (SLE) patients for developing renal manifestations. The present invention further relates to polypeptides binding to one or more components of neutrophil extracellular traps (NET(s)) and to kits comprising components suitable to carry out the methods provided herein.