公开(公告)号：EP1809678B1

公开(公告)日：2013-05-22

申请号：EP05851461.3

申请日：2005-11-10

申请人： Mayo Foundation for Medical Education and Research

发明人： WANG, Shangfeng ,  LU, Lichun ,  YASZEMSKI, Michael, J.

IPC分类号： C08F20/00 ,  A61F2/00 ,  C08J9/26 ,  A61K31/77 ,  C08G65/332 ,  C08G63/02 ,  B32B27/00 ,  C08K3/32 ,  C08G63/08

CPC分类号： C08G63/912 ,  A61L27/18 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  C08G63/08 ,  C08L67/06 ,  C08L67/04

公开(公告)号：EP1812481B1

公开(公告)日：2012-01-11

申请号：EP05851973.7

申请日：2005-11-18

申请人： Mayo Foundation for Medical Education and Research

发明人： WANG, Shangfeng ,  YASZEMSKI, Michael, J. ,  LU, Lichun ,  CURRIER, Bradford, L.

IPC分类号： C08F20/00 ,  C08G63/02 ,  A61F2/00 ,  B32B27/00 ,  C08G63/08 ,  C08G81/00 ,  C08K5/00 ,  A61L27/42 ,  C08J9/26

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

摘要： Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in­ situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

公开(公告)号：EP1812481A2

公开(公告)日：2007-08-01

申请号：EP05851973.7

申请日：2005-11-18

申请人： Mayo Foundation for Medical Education and Research

发明人： WANG, Shangfeng ,  YASZEMSKI, Michael, J. ,  LU, Lichun ,  CURRIER, Bradford, L.

IPC分类号： C08F20/00 ,  C08G63/02 ,  A61F2/00 ,  B32B27/00

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

摘要： Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in­ situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

公开(公告)号：EP1809678A2

公开(公告)日：2007-07-25

申请号：EP05851461.3

申请日：2005-11-10

申请人： Mayo Foundation for Medical Education and Research

发明人： WANG, Shangfeng ,  LU, Lichun ,  YASZEMSKI, Michael, J.

IPC分类号： C08F20/00 ,  A61F2/00 ,  C08J9/26 ,  A61K31/77 ,  C08G65/332 ,  C08G63/02 ,  B32B27/00 ,  C08K3/32 ,  C12N5/06

CPC分类号： C08G63/912 ,  A61L27/18 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  C08G63/08 ,  C08L67/06 ,  C08L67/04

摘要： Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.