公开(公告)号：EP0705344A1

公开(公告)日：1996-04-10

申请号：EP94920351.0

申请日：1994-06-24

申请人： McMASTER UNIVERSITY

发明人： GRAHAM, Frank, L. ,  BETT, Andrew ,  PREVEK, Ludvik ,  HADDARA, Wael

IPC分类号： C12N15 ,  C12N7 ,  C12P21

CPC分类号： C12N15/86 ,  A01K2217/05 ,  C12N2710/10343 ,  C12N2800/30

摘要： The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and optionally insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention also comprises the use of these vectors in introducing genes into cells, in making vaccines and in gene therapy.