专利检索 ap:("MedImmune, LLC" OR "Medimmune Limited") AND inv:"PRIVEZENTZEV, Cyril" 第 1 页

1.

发明公开
CTLA-4 VARIANTS 审中-公开
标题翻译： CTLA-4变异

公开(公告)号：EP2863936A1

公开(公告)日：2015-04-29

申请号：EP13787673.6

申请日：2013-03-11

申请人： MedImmune, LLC , Medimmune Limited

发明人： MINTER, Ralph , DOUTHWAITE, Julie , MOISAN, Jacques , BOWEN, Michael , RUST, Steve , PRIVEZENTZEV, Cyril

IPC分类号： A61K38/16 , C07K1/00

CPC分类号： C07K14/70521 , A61K38/00 , C07K2319/30

摘要： Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.