公开(公告)号：EP2102238A2

公开(公告)日：2009-09-23

申请号：EP07863135.5

申请日：2007-12-20

申请人： Medarex, Inc. ,  Pfizer, Inc.

发明人： XU, Xu ,  BEDIAN, Vahe ,  MEADDOUGH, Erika ,  HUANG, Haichun ,  YANG, Lan ,  TOY, Kristopher ,  SRINIVASAN, Mohan ,  BADKAR, Advait V.

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K16/2884 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment.

公开(公告)号：EP2403878A1

公开(公告)日：2012-01-11

申请号：EP10708470.9

申请日：2010-03-05

申请人： Medarex, Inc. ,  Oxford Biotherapeutics Ltd.

发明人： TERRETT, Jonathan, Alexander ,  LEBLANC, Heidi ,  HUANG, Haichun ,  MEADDOUGH, Erika ,  PAN, Chin ,  CHEN, Bingliang ,  RAO-NAIK, Chetana

IPC分类号： C07K16/28

CPC分类号： C07K16/3007 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或对ADCC或免疫偶联物的增强的效力，其以高亲和力特异性结合CADM1。 还提供了编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。