公开(公告)号：EP1976883B1

公开(公告)日：2012-10-03

申请号：EP07718000.8

申请日：2007-01-17

申请人： Medarex, Inc. ,  Synthon B.V.

发明人： BLACK, Amelia, Nancy ,  PASSMORE, David, B. ,  SRINIVASAN, Mohan ,  DICKEY, Lynn, F. ,  COX, Kevin, M. ,  PEELE, Charles, G. ,  WANG, Ming-Bo

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/13 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732

公开(公告)号：EP1976883A2

公开(公告)日：2008-10-08

申请号：EP07718000.8

申请日：2007-01-17

申请人： MEDAREX, INC.

发明人： BLACK, Amelia, Nancy ,  PASSMORE, David, B. ,  SRINIVASAN, Mohan ,  DICKEY, Lynn, F. ,  COX, Kevin, M. ,  PEELE, Charles, G. ,  WANG, Ming-Bo

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/13 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732

摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to Iyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.