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公开(公告)号：EP3389620A1
公开(公告)日：2018-10-24
申请号：EP15910892.7
申请日：2015-12-15
发明人： TUROVETS, Nikolay
CPC分类号： A61K8/14 , A61K8/64 , A61K2800/91 , A61Q19/02
摘要： Compositions and methods for topical treatment of the hyperpigmented lesions of melasma are presented. Such compositions include defensins in concentrations that are below those that exhibit antimicrobial activity, and can be in the form of a topically applied gel, lotion, wash, shampoo, cream, or mask. Various formulations for such compositions, which can include various pharmaceutically acceptable stabilizers, emollients, and fragrances, are provided.
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公开(公告)号：EP3157504B1
公开(公告)日：2019-08-07
申请号：EP15810115.4
申请日：2015-06-16
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公开(公告)号：EP3157504A1
公开(公告)日：2017-04-26
申请号：EP15810115.4
申请日：2015-06-16
CPC分类号： A61K8/64 , A61K8/14 , A61K8/553 , A61K2800/74 , A61Q5/02 , A61Q19/00 , A61Q19/007 , A61Q19/08 , A61Q19/10
摘要： The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.
摘要翻译： 本发明主题涉及即用型局部化妆品制剂，其包含至少一种以亚抗微生物有效浓度存在的防御素。 令人惊讶的是，即使在如此低的浓度下，防御素也会将毛囊中的LGR6 +干细胞募集到滤泡间隙中。 在本发明的局部用化妆品制剂中包含防御素可以降低皱纹深度，皱纹长度，皱纹宽度，孔径，皮肤表面纹理不规则性，油性，棕色斑点和未损伤皮肤中的红色斑点中的一种或多种，因此减少 明显的年龄。
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公开(公告)号：EP3586821A1
公开(公告)日：2020-01-01
申请号：EP19190130.5
申请日：2015-06-16
摘要： The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.
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