公开(公告)号：EP1948593A2

公开(公告)日：2008-07-30

申请号：EP06850464.6

申请日：2006-10-27

申请人： Medichem, S.A.

发明人： AUQUER PEDEMONTE, Ignasi

IPC分类号： C07C303/40 ,  C07C311/37 ,  A61K31/18 ,  A61P13/08

CPC分类号： C07C303/40 ,  C07B2200/07 ,  C07C311/37

摘要： The invention relates, in general, to the preparation of (R)(-)tamsulosin free base by reaction of (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide or an addition salt thereof with 1 -(2-bromoethoxy)-2-ethoxybenzene in a polar aprotic solvent in the presence of an organic base. More particularly, the invention relates to a process for preparing pure solid crystalline (R)(-)tamsulosin in its free base form as a precursor for the production of (R)(-)tamsulosin hydrochloride.

公开(公告)号：EP1893602A2

公开(公告)日：2008-03-05

申请号：EP06831533.2

申请日：2006-05-05

申请人： Medichem, S.A.

发明人： AUQUER PEDEMONTE, Ignasi

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： The invention relates, in general, to a new solid crystalline form of pantoprazole free acid (denominated 'Form III'), salts derived therefrom (e.g., pantoprazole sodium and pantoprazole sodium sesquihydrate) and methods for producing the same. The invention further includes formulating pantoprazole free acid Form III, salts derived therefrom (e.g., pantoprazole sodium and pantoprazole sodium sesquihydrate) and/or in vivo cleavable prodrugs thereof (collectively 'the compounds of the invention') into readily usable dosage units for the therapeutic treatment (including prophylactic treatment) of mammals, including humans.