专利检索 ap:("Medichem, S.A.") AND inv:"DURAN LOPEZ, Ernest" 第 1 页

1.

发明授权
NEW CRYSTALLINE SALT FORMS OF A 5,6,7,8-TETRAHYDRO-1,2,4- TRIAZOLO[4,3-A]PYRAZINE DERIVATIVE 有权
标题翻译：甲5,6,7,8- TETRA HYDRO-1,2,4-三唑并[4,3-a]吡嗪衍生物的新结晶盐形式

公开(公告)号：EP2324027B1

公开(公告)日：2016-02-24

申请号：EP09781249.9

申请日：2009-07-29

申请人： Medichem, S.A.

发明人： WINTER, Stephen Benedict David , BENITO VELEZ, Monica , DURAN LOPEZ, Ernest

IPC分类号： C07D487/04

CPC分类号： C07D487/04

2.

发明公开
NEW CRYSTALLINE SALT FORMS OF A 5,6,7,8-TETRAHYDRO-1,2,4- TRIAZOLO[4,3-A]PYRAZINE DERIVATIVE 有权
标题翻译：甲5,6,7,8- TETRA HYDRO-1,2,4-三唑并[4,3-a]吡嗪衍生物的新结晶盐形式

公开(公告)号：EP2324027A2

公开(公告)日：2011-05-25

申请号：EP09781249.9

申请日：2009-07-29

申请人： Medichem, S.A.

发明人： WINTER, Stephen Benedict David , BENITO VELEZ, Monica , DURAN LOPEZ, Ernest

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： This invention provides novel crystalline acid salt forms of 7-[(3
R )-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-
a ]pyrazine,
i.e . sitagliptin, to processes for their preparation and isolation, and to pharmaceutical compositions comprising the same.