公开(公告)号：EP2456750A2

公开(公告)日：2012-05-30

申请号：EP10754901.6

申请日：2010-07-20

申请人： Medichem, S.A.

发明人： MASLLORENS LLINÀS, Ester ,  DURAN LOPEZ, Ernesto

IPC分类号： C07C211/42 ,  A61K31/135 ,  A61P25/16

CPC分类号： C07C211/42 ,  C07C2602/08

摘要： The invention relates to rasagiline mesylate with improved flowability and compressibility and with advantageously reduced stickiness, to processes for the preparation thereof, and to the use thereof for milling and for preparing pharmaceutical formulations. Also, the invention relates to a method for improving the flowability and / or alleviating the stickiness of rasagiline mesylate having a very poor flowability and / or showing undesirable stickiness.

摘要翻译： 本公开总体上涉及具有改善的流动性和有利地降低的粘性的甲磺酸雷沙吉兰，其制备方法及其用于研磨和用于制备药物制剂的用途。 还公开了改善具有非常差的流动性和/或显示不期望的粘性的甲磺酸雷沙吉兰的流动性和/或减轻粘性的方法。