公开(公告)号：EP3341004A1

公开(公告)日：2018-07-04

申请号：EP16839995.4

申请日：2016-08-23

申请人： Medimmune, LLC

发明人： WANG, Qun ,  RAJAN, Saravanan ,  CHANG, Chew-Shun ,  HEIDBRINK THOMPSON, Jenny ,  LIN, Hung-Yu ,  STOVER, Charles Kendall ,  PENNINI, Meghan ,  DALL'ACQUA, William ,  CHOWDHURY, Partha S. ,  XIAO, Xiaodong

IPC分类号： A61K38/00 ,  A61K39/108 ,  A61K39/395 ,  C07K14/26 ,  C07K16/12 ,  C07K16/18

CPC分类号： C07K16/1228 ,  A61K39/0266 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure provides MrkA binding proteins, e.g., antibodies or antigen binding fragments thereof that bind to MrkA and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering MrkA binding proteins, e.g., antibodies or antigen-binding fragments thereof, MrkA polypeptides, immunogenic fragments thereof, or polynucleotides encoding MrkA or immunogenic fragments thereof to the subject.