公开(公告)号：EP1089723A1

公开(公告)日：2001-04-11

申请号：EP99930617.8

申请日：1999-06-22

申请人： Medinox, Inc.

发明人： LAI, Ching-San ,  VASSILEV, Vassil

IPC分类号： A61K31/105

CPC分类号： A61K31/145 ,  A61K31/4025 ,  A61K31/5377 ,  A61K45/06 ,  Y02A50/411 ,  Y10S514/825 ,  Y10S514/838 ,  Y10S514/851 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/903 ,  Y10S514/909 ,  Y10S514/912 ,  Y10S514/925

摘要： The present invention provides a novel dithiocarbamate disulfide dimer useful in various therapeutic treatments, either alone or in combination with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with an agent that inactivates (or inhibits the production of) species that induce the expression of nitric oxide synthase to reduce the production of such species, while, at the same time reducing nitric oxide levels in the subject. In another embodiment, free iron ion levels are reduced in a subject by administration of a disulfide derivative of a dithiocarbamate(s) to scavenge free iron ions, for example, in subjects undergoing anthracycline chemotherapy. In another embodiment, cyanide levels are reduced in a subject by administration of a disulfide derivative of a dithiocarbamate so as to bind cyanide in the subject. In a further aspect, the present invention relates to compositions and formulations useful in such therapeutic methods.