公开(公告)号：EP4286524A3

公开(公告)日：2024-03-06

申请号：EP23200273.3

申请日：2018-07-30

申请人： Melt&Marble AB

发明人： HUANG, Mingtao ,  KRIVORUCHKO, Anastasia ,  DAVID, Florian ,  NIELSEN, Jens

IPC分类号： C12N15/80 ,  C12P1/02

摘要： The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.

公开(公告)号：EP4286524A2

公开(公告)日：2023-12-06

申请号：EP23200273.3

申请日：2018-07-30

申请人： Melt&Marble AB

发明人： HUANG, Mingtao ,  KRIVORUCHKO, Anastasia ,  DAVID, Florian ,  NIELSEN, Jens

IPC分类号： C12P1/02

摘要： The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.

公开(公告)号：EP4267728A2

公开(公告)日：2023-11-01

申请号：EP21841043.9

申请日：2021-12-21

申请人： Melt&Marble AB

发明人： DAVID, Florian ,  GONCALVES TEIXEIRA, Paulo Alexandre ,  KRIVORUCHKO, Anastasia

IPC分类号： C12N9/10 ,  C12N9/20 ,  C12P7/6436 ,  C12P7/6445