公开(公告)号：EP2968539A1

公开(公告)日：2016-01-20

申请号：EP14722878.7

申请日：2014-03-14

申请人： Memorial Sloan Kettering Cancer Center

发明人： SCHEINBERG, David ,  DUBROVSKY, Leonid

IPC分类号： A61K39/395 ,  A61K45/06 ,  A61K31/506 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07K16/32 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/3038 ,  A61K2300/00

摘要： In an attempt to improve primary disease responsiveness and/or to overcome resistant disease, the present disclosure provides a method for treating or inhibiting the proliferation of a WT-1 -dependent cancer comprising providing to a subject in need thereof a therapeutically effective amount of a tyrosine kinase inhibitor along with an anti-WT-1 /HLA antibody, that is, an antibody that specifically binds to a peptide of Wilms' tumor protein (WT-1 ) presented on the surface of the cancer cells in an HLA-restricted fashion.