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公开(公告)号：EP4138865A2
公开(公告)日：2023-03-01
申请号：EP21793613.7
申请日：2021-04-26
申请人： Memorial Sloan Kettering Cancer Center , Millennium Pharmaceuticals, Inc. , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
发明人： FEUCHT, Judith , MANSILLA-SOTO, Jorge , RIVIERE, Isabelle , SADELAIN, Michel , VINCENT, Loic , SHAPIRO, Gary , NG, Mei Rosa , TAVARES, Dan , HE, Xingyue
IPC分类号： A61K35/17 , A61K39/395 , C07K14/705
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公开(公告)号：EP4330275A2
公开(公告)日：2024-03-06
申请号：EP22796477.2
申请日：2022-04-25
申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases , Millennium Pharmaceuticals, Inc.
IPC分类号： C07K14/725 , C07K14/705 , C07K16/30 , C07K19/00
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公开(公告)号：EP3620521A1
公开(公告)日：2020-03-11
申请号：EP19185730.9
申请日：2015-09-04
发明人： SADELAIN, Michel , RIVIERE, Isabelle , MANSILLA-SOTO, Jorge , WANG, Xiuyan , STAMATOYANNOPOULOS, George , STAMATOYANNOPOULOS, John , LIU, Mingdong
IPC分类号： C12N15/113 , A61K48/00 , C12N15/85 , C12N15/867
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
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公开(公告)号：EP4438115A2
公开(公告)日：2024-10-02
申请号：EP24178429.7
申请日：2015-09-04
发明人： SADELAIN, Michel , RIVIERE, Isabelle , MANSILLA-SOTO, Jorge , WANG, Xiuyan , STAMATOYANNOPOULOS, George , STAMATOYANNOPOULOS, John , LIU, Mingdong
IPC分类号： A61P7/06
CPC分类号： C07K14/805 , C12N9/22 , C12N15/86 , C12N2740/1504320130101 , C12N2830/4020130101 , C12N2740/1604320130101 , C12N2830/1520130101 , C12N2830/4820130101 , C12N2830/5020130101 , A61K48/0058 , C12N15/85 , C12N2830/00820130101 , C12N2830/3020130101 , C12N2830/4620130101 , A61K48/0066 , A61P7/06
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
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5.发明公开
公开(公告)号：EP3443075A2
公开(公告)日：2019-02-20
申请号：EP17735670.6
申请日：2017-04-14
IPC分类号： C12N5/0783 , C07K14/725 , C12N9/22 , C12N15/63
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公开(公告)号：EP3189143A1
公开(公告)日：2017-07-12
申请号：EP15837740.8
申请日：2015-09-04
发明人： SADELAIN, Michel , RIVIERE, Isabelle , MANSILLA-SOTO, Jorge , WANG, Xiuyan , STAMATOYANNOPOULOS, George , STAMATOYANNOPOULOS, John , LIU, Mingdong
IPC分类号： C12N15/113
CPC分类号： A61K48/0066 , A61K48/0058 , C07K14/805 , C12N9/22 , C12N15/85 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2740/16043 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/40 , C12N2830/46 , C12N2830/48 , C12N2830/50
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
摘要翻译： 本发明公开的主题提供了允许表达珠蛋白基因或其功能部分的表达盒，包含其的载体以及用这种表达盒和载体转导的细胞。 本发明公开的主题进一步提供了用于治疗受试者中的血红蛋白病的方法，其包括向受试者施用有效量的这样的转导细胞。
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7.发明公开
公开(公告)号：EP4180519A1
公开(公告)日：2023-05-17
申请号：EP22197444.7
申请日：2017-04-14
IPC分类号： C12N5/0783 , C07K14/725 , C12N9/22 , C12N15/63
摘要： The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a T cell for use in a method of treating with chimeric antigen receptor (CAR) therapy a subject having a disease, wherein a recombinant nucleic acid sequence encoding a CAR is integrated at a first site within the genome of the T cell such that the CAR is expressed by the T cell at the surface of the T cell, wherein the expression of the nucleic acid sequence is under the control of an endogenous promoter of a T cell receptor (TCR) complex gene, and wherein the integration of the nucleic acid sequence at the first site prevents expression of a functional TCR complex at the surface of the cell.
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公开(公告)号：EP3189143B1
公开(公告)日：2019-08-07
申请号：EP15837740.8
申请日：2015-09-04
发明人： SADELAIN, Michel , RIVIERE, Isabelle , MANSILLA-SOTO, Jorge , WANG, Xiuyan , STAMATOYANNOPOULOS, George , STAMATOYANNOPOULOS, John , LIU, Mingdong
IPC分类号： C12N15/113 , A61K48/00 , C12N15/85 , C12N15/867
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